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A future COVID-19 vaccine will not work without sufficient uptake, and some are considering mandates to get that uptake. Some scholars have gone so far as to call for compulsory vaccination for all U.S. residents in a recent USA Today column.
We believe premature mandates won’t work. In fact, they could backfire spectacularly.
There are several reasons for this. First, once we have an approved vaccine, we will not have enough doses to go around for those who want them.
Forget mandates: even if all goes remarkably well, we will begin by producing and distributing tens of millions of doses—not the hundreds of millions needed to cover the entire United States.
where can i buy corona vaccine record card ,Prior to the pandemic, funding bodies increasingly required investigators to involve patients throughout the research process – from setting priorities to translating results into practice. “It gives an opportunity for the patient to become part of the solution,” says Lebouché.
With COVID-19, these requirements mostly fell by the wayside. “Of course, COVID-19 is an exceptional circumstance. But you can ask the population, ‘What do you think? What do you need?’ And this was not done.”
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Yet more than a year later, many funding calls for COVID-19 research still don’t mention the need to include patients or the public as partners.
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According to Weijs, the pandemic has also raised upstream questions about the purpose of patient partnership. “What is the goal of involving patients and the public in research? Are we trying to share power with them? Because right now, that’s not how it works.”
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Some early studies suggest that ten to twenty percent of people with COVID-19 will experience symptoms lasting longer than a month. A majority of those who were admitted to hospital with severe disease report long-term problems, including fatigue and shortness of breath About 5–10% of patients admitted to hospital progress to severe or critical disease, including pneumonia and acute respiratory failure.
By a variety of mechanisms, the lungs are the organs most affected in COVID-19. In people requiring hospital admission, up to 98% of CT scans performed show lung abnormalities after 28 days of illness even if they had clinically improved.
People with advanced age, severe disease, prolonged ICU stays, or who smoke are more likely to have long-lasting effects, including pulmonary fibrosis. Overall, approximately one-third of those investigated after four weeks will have findings of pulmonary fibrosis or reduced lung function as measured by DLCO, even in asymptomatic people, but with the suggestion of continuing improvement with the passing of more time.
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As of May 12, Canada has reported one case of vaccine-induced immune thrombotic thrombocytopenia (VITT) in every 83,000 people who received a first dose of the AstraZeneca shot.
Tam noted that the rate of VITT seems to be lower after the second dose of the AstraZeneca vaccine. “Right now, it’s one in 600,000 people but that could change,” she said at a briefing.
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However, the evidence for mixing and matching COVID-19 vaccines is still emerging.
NACI’s recommendations are based on three studies, each involving several hundred participants, which reported no serious adverse events among adults who received a Pfizer shot after a first dose of the AstraZeneca vaccine.
One of the studies noted an increase in short-term side effects including fatigue, headaches, and chills compared to people who received the AstraZeneca vaccine for both shots.
And none of the studies were large enough to capture rare adverse events like VITT. Even so, NACI concluded that mixed schedules appear to have an “acceptable safety profile.”
Some experts have speculated that mixing and matching COVID-19 vaccines could boost their effectiveness by triggering stronger or broader immune responses.
Preliminary data from the CombiVacS trial in Spain indicated that humoral immune responses after a first dose of the AstraZeneca vaccine increased following a Pfizer booster. But there are no data comparing those results to the immune responses triggered by two doses of the AstraZeneca vaccine.
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